CD4Diagnostic

The CD4Diagnostic intervention class is similar to SimpleDiagnostic, but adds the ability to divide individual populations based on configurable CD4 count ranges. It uses the individual’s current actual CD4 count, regardless of when a CD4 test has been performed. An event can then be applied based on the Low or High group to which the individuals have been moved.

Note

Parameters are case-sensitive. For Boolean parameters, set to 1 for true or 0 for false. JSON does not permit comments, but you can add “dummy” parameters to add contextual information to your files.

The table below describes all possible parameters with which this class can be configured. The JSON example that follows shows one potential configuration.

Parameter Data type Minimum Maximum Default Description Example
Event string NA NA NA The user-defined name of the diagnostic event.
{
    "Intervention_Config": {
        "class": "CD4Diagnostic",
        "CD4_Thresholds": [{
            "Low": 100,
            "High": 500,
            "Event": "CD4Measured0"
        }]
    }
}
High float 0 1000 NA The high end of the diagnostic level.
{
    "Intervention_Config": {
        "class": "CD4Diagnostic",
        "CD4_Thresholds": [{
            "Low": 100,
            "High": 500,
            "Event": "CD4Measured0"
        }]
    }
}
Low float 0 1000 NA The low end of the diagnostic level.
{
    "Intervention_Config": {
        "class": "CD4Diagnostic",
        "CD4_Thresholds": [{
            "Low": 100,
            "High": 500,
            "Event": "CD4Measured0"
        }]
    }
}
CD4_Thresholds array of JSON objects NA NA NA This parameter associates ranges of CD4 counts with events that should occur for individuals whose CD4 counts fall into those ranges.
{
    "Intervention_Config": {
        "class": "CD4Diagnostic",
        "CD4_Thresholds": [{
            "Low": 100,
            "High": 500,
            "Event": "CD4Measured0"
        }]
    }
}
Base_Sensitivity float 0 1 1 The sensitivity of the diagnostic. This sets the proportion of the time that individuals with the condition being tested receive a positive diagnostic test. When set to 1, the diagnostic always accurately reflects the condition. When set to zero, then individuals who have the condition always receive a false-negative diagnostic test.
{
    "Base_Sensitivity": 0.8
}
Base_Specificity float 0 1 1 The specificity of the diagnostic. This sets the proportion of the time that individuals without the condition being tested receive a negative diagnostic test. When set to 1, the diagnostic always accurately reflects the lack of having the condition. When set to zero, then individuals who do not have the condition always receive a false-positive diagnostic test.
{
    "Base_Specificity": 0.9
}
Cost_To_Consumer float 0 3.40E+3 1 The unit ‘cost’ assigned to the diagnostic. Setting Cost_To_Consumer to zero for all other interventions, and to a non-zero amount for one intervention, provides a convenient way to track the number of times the intervention has been applied in a simulation.
{
    "Cost_To_Consumer": 0.333
}
Days_To_Diagnosis float 0 3.40E+3 0 The number of days from test until diagnosis.
{
    "Days_To_Diagnosis": 0.0
}
Treatment_Fraction float 0 1 1 The fraction of positive diagnoses that are treated.
{
    "Intervention_Config": {
        "Base_Sensitivity": 1.0,
        "Base_Specificity": 1.0,
        "Cost_To_Consumer": 0.0,
        "Days_To_Diagnosis": 0.0,
        "Event_Or_Config": "Event",
        "Positive_Diagnosis_Event": "TestedPositive_CureMeNow",
        "Treatment_Fraction": 1.0,
        "class": "SimpleDiagnostic"
    }
}
Dont_Allow_Duplicates boolean NA NA 0 If an individual’s container has an intervention, set to true (1) to prevent them from receiving another copy of the intervention. Supported by all intervention classes.
{
    "Dont_Allow_Duplicates": 0
}
Disqualifying_Properties string NA NA NA A list of IndividualProperty key:value pairs that cause an intervention to be aborted (persistent interventions will stop being distributed to individuals with these values). See NodeProperties and IndividualProperties parameters for more information. Generally used to control the flow of health care access. For example, to prevent the same individual from accessing health care via two different routes at the same time.
{
    "Disqualifying_Properties": [
        "InterventionStatus:LostForever"
    ]
}
Intervention_Name string NA NA NA The optional name used to refer to this intervention as a means to differentiate it from others that use the same class.
{
    "Intervention_Name":"Diagnostic_Sample"
}
New_Property_Value string NA NA NA An optional IndividualProperty key:value pair that will be assigned when the intervention is distributed. See NodeProperties and IndividualProperties parameters for more information. Generally used to indicate the broad category of health care cascade to which an intervention belongs to prevent individuals from accessing care through multiple pathways. For example, if an individual must already be taking a particular medication to be prescribed a new one.
{
    "New_Property_Value": "InterventionStatus:None"
}
{
    "Campaign_Name": "4a_ARTRetention_Depends_on_Time_CD4_Demographics",
    "Default_Campaign_Path": "defaults/hiv_default_campaign.json",
    "Use_Defaults": 1,
    "Events": [{
        "class": "CampaignEventByYear",
        "Event_Name": "",
        "Start_Year": 1990,
        "Nodeset_Config": {
            "class": "NodeSetAll"
        },
        "Event_Coordinator_Config": {
            "class": "StandardInterventionDistributionEventCoordinator",
            "Intervention_Config": {
                "class": "NodeLevelHealthTriggeredIV",
                "Trigger_Condition_List": [
                    "OnART1"
                ],
                "Actual_IndividualIntervention_Config": {
                    "class": "CD4Diagnostic",
                    "CD4_Thresholds": [{
                            "Low": 0,
                            "High": 200,
                            "Event": "OnART4"
                        },
                        {
                            "Low": 200,
                            "High": 100000000,
                            "Event": "OnART7"
                        }
                    ]
                }
            }
        }
    }]
}