# Malaria research at IDM¶

Malaria research at IDM is progressive and dynamic. For the current research, research team profiles, and a full list of published papers from IDM’s malaria group, see the IDM Malaria Research Website.

## IDM malaria publications¶

Information specific to the components of the model described previously can be found in the following list of select IDM malaria publications.

### Vector model¶

- Eckhoff, 2013. Mathematical models of within-host and transmission dynamics to determine effects of
malaria interventions in a variety of transmission settings.
*Am J Trop Med Hyg*. 88(5):817-27 - Eckhoff, 2011. A malaria transmission-directed model of mosquito life cycle and ecology.
*Malaria Journal*. 10:303

### Infection and immunity: Within-host parasite dynamics¶

- Lawniczak & Eckhoff, 2016. A computational lens for sexual-stage transmission, reproduction, fitness and kinetics in
Plasmodium falciparum.
*Malaria Journal*. 15:487 - Cameron,
*et al*., 2015. Defining the relationship between infection prevalence and clinical incidence of Plasmodium falciparum malaria.*Nature Communications*. 6:8170 - Ouedraogo,
*et al*., 2015. Dynamics of the Human Infectious Reservoir for Malaria Determined by Mosquito Feeding Assays and Ultrasensitive Malaria Diagnosis in Burkina Faso.*Journal of Infectious Diseases*. 213(1):90-99 - Gerardin, Ouedraogo, McCarthy, Eckhoff and Wenger, 2015. Characterization of the infectious reservoir of malaria
with an agent-based model calibrated to age-stratified parasite densities and infectiousness.
*Malaria Journal*. 14:231 - Eckhoff, 2012. Malaria parasite diversity and transmission intensity affect development of parasitological
immunity in a mathematical model.
*Malaria Journal*. 11:419 - Eckhoff, 2012. P. falciparum Infection Durations and Infectiousness Are Shaped by Antigenic Variation
and Innate and Adaptive Host Immunity in a Mathematical Model.
*PLOS one*. 7(9)

### Outcrossing of parasite genetics¶

- Daniels,
*et al*., 2015. Modeling malaria genomics reveals transmission decline and rebound in Senegal.*PNAS*. 112(22):7067-7072

### Antimalarial drugs¶

- Bellinger,
*et al*., 2016. Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals.*Science Translational Medicine*. 8(365). - Gerardin, Eckhoff and Wenger, 2015. Mass campaigns with antimalarial drugs: a modeling comparison of
artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and
elimination.
*BMC Infectious Diseases*. 15:144

### Vaccines¶

- Penny,
*et al*., 2016. Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models.*The Lancet*. 387(100016): 367-375 - McCarthy, Wenger, Huynh and Eckhoff, 2015. Calibration of an intrahost malaria model and parameter
ensemble evaluation of a pre-erythrocytic vaccine.
*Malaria Journal*. 14:6 - Wenger & Eckhoff, 2013. A mathematical model of the impact of present and future malaria vaccines.
*Malaria Journal*. 12:126

### Spatial models¶

- Nikolov,
*et al*., 2016. Malaria Elimination Campaigns in the Lake Kariba Region of Zambia: a Spatial Dynamical Model.*PLOS Computational Biology*. - Marshall,
*et al*., 2016. Key traveler groups of relevance to spatial malaria transmission: a survey of movement patterns in four sub-Saharan African countries.*Malaria Journal*. 15(200) - Gerardin,
*et al*., 2016. Optimal Population-Level Infection Detection Strategies for Malaria Control and Elimination in a Spatial Model of Malaria Transmission.*PLOS Computational Biology*. - Eckhoff,
*et al*., 2015. From puddles to planet: modeling approaches to vector-borne diseases at varying resolution and scale.*Current Opinion in Insect Science*. 10:118-123

### Interventions¶

- Eckhoff, Wenger, Godfray and Burt, 2016. Impact of mosquito gene drive on malaria elimination in a computational model with
explicit spatial and temporal dynamics.
*PNAS*. 114(2) - Bhatt,
*et al*., 2015. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015.*Nature*. 526:207-211