Malaria research at IDM¶
Malaria research at IDM is progressive and dynamic. For the current research, research team profiles, and a full list of published papers from IDM’s malaria group, see the IDM Malaria Research Website.
IDM malaria publications¶
Information specific to the components of the model described previously can be found in the following list of select IDM malaria publications.
- Eckhoff, 2013. Mathematical models of within-host and transmission dynamics to determine effects of malaria interventions in a variety of transmission settings. Am J Trop Med Hyg. 88(5):817-27
- Eckhoff, 2011. A malaria transmission-directed model of mosquito life cycle and ecology. Malaria Journal. 10:303
Infection and immunity: Within-host parasite dynamics¶
- Lawniczak & Eckhoff, 2016. A computational lens for sexual-stage transmission, reproduction, fitness and kinetics in Plasmodium falciparum. Malaria Journal. 15:487
- Cameron, et al., 2015. Defining the relationship between infection prevalence and clinical incidence of Plasmodium falciparum malaria. Nature Communications. 6:8170
- Ouedraogo, et al., 2015. Dynamics of the Human Infectious Reservoir for Malaria Determined by Mosquito Feeding Assays and Ultrasensitive Malaria Diagnosis in Burkina Faso. Journal of Infectious Diseases. 213(1):90-99
- Gerardin, Ouedraogo, McCarthy, Eckhoff and Wenger, 2015. Characterization of the infectious reservoir of malaria with an agent-based model calibrated to age-stratified parasite densities and infectiousness. Malaria Journal. 14:231
- Eckhoff, 2012. Malaria parasite diversity and transmission intensity affect development of parasitological immunity in a mathematical model. Malaria Journal. 11:419
- Eckhoff, 2012. P. falciparum Infection Durations and Infectiousness Are Shaped by Antigenic Variation and Innate and Adaptive Host Immunity in a Mathematical Model. PLOS one. 7(9)
Outcrossing of parasite genetics¶
- Daniels, et al., 2015. Modeling malaria genomics reveals transmission decline and rebound in Senegal. PNAS. 112(22):7067-7072
- Bellinger, et al., 2016. Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals. Science Translational Medicine. 8(365).
- Gerardin, Eckhoff and Wenger, 2015. Mass campaigns with antimalarial drugs: a modeling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination. BMC Infectious Diseases. 15:144
- Penny, et al., 2016. Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models. The Lancet. 387(100016): 367-375
- McCarthy, Wenger, Huynh and Eckhoff, 2015. Calibration of an intrahost malaria model and parameter ensemble evaluation of a pre-erythrocytic vaccine. Malaria Journal. 14:6
- Wenger & Eckhoff, 2013. A mathematical model of the impact of present and future malaria vaccines. Malaria Journal. 12:126
- Nikolov, et al., 2016. Malaria Elimination Campaigns in the Lake Kariba Region of Zambia: a Spatial Dynamical Model. PLOS Computational Biology.
- Marshall, et al., 2016. Key traveler groups of relevance to spatial malaria transmission: a survey of movement patterns in four sub-Saharan African countries. Malaria Journal. 15(200)
- Gerardin, et al., 2016. Optimal Population-Level Infection Detection Strategies for Malaria Control and Elimination in a Spatial Model of Malaria Transmission. PLOS Computational Biology.
- Eckhoff, et al., 2015. From puddles to planet: modeling approaches to vector-borne diseases at varying resolution and scale. Current Opinion in Insect Science. 10:118-123
- Eckhoff, Wenger, Godfray and Burt, 2016. Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics. PNAS. 114(2)
- Bhatt, et al., 2015. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 526:207-211